Astigmatism Research Today is a free monthly online journal that collates and summarizes the latest research about Astigmatism, including details on cornea, retina, treatment, types, signs, tests.

Quantitative analysis of chondroitin sulfate in tear fluids following laser in situ keratomileusis.

Nishio M, Arai K

Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.

PURPOSE: To report chondroitin sulfate (CS) concentrations in tear fluid following laser in situ keratomileusis (LASIK). METHODS: Fourteen eyes that underwent LASIK were enrolled. We measured the CS isomers chondroitin 4 sulfate and chondroitin 6 sulfate using an enzyme-linked immunosorbent assay preoperatively and postoperatively on days 1 and 4, week 1, and 1 and 3 months. RESULTS: The chondroitin 4 sulfate concentration remained unchanged from preoperative values. The chondroitin 6 sulfate concentration increased temporarily 1 day postoperatively and gradually decreased thereafter. CONCLUSIONS: CS in tear fluids participates in wound healing after LASIK. Clarifying its role in tear fluids will contribute to improved LASIK outcomes.

Published 29 September 2006 in Ophthalmic Res, 38(5): 274-9.
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